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Article

A novel human cell culture model to study visceral smooth muscle phenotypic modulation in health and disease.

American journal of physiology. Cell physiology - 1 Oct 2018

Vaes Rianne D W, van den Berk Linda, Boonen Bas, van Dijk David P J, Olde Damink Steven W M, Rensen Sander S

Abstract excerpt

Adaptation of the smooth muscle cell (SMC) phenotype is essential for homeostasis and is often involved in pathologies of visceral organs (e.g., uterus, bladder, gastrointestinal tract). In vitro studies of the behavior of visceral SMCs under (patho)-physiological conditions are hampered by a spontaneous, uncontrolled phenotypic modulation of visceral SMCs under regular tissue culture conditions. We aimed to...

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Identifiers

PMID: 30044660
DOI: 10.1152/ajpcell.00167.2017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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