Article
No evidence for involvement of SDHD in neuroblastoma pathogenesis.
BMC cancer - 24 Aug 2004
De Preter Katleen, Vandesompele Jo, Hoebeeck Jasmien, Vandenbroecke Caroline, Smet Jöel, Nuyts Annick, Laureys Geneviève, Combaret Valérie, Van Roy Nadine, Roels Frank, Van Coster Rudy, Praet Marleen, De Paepe Anne, Speleman Frank
Abstract excerpt
BACKGROUND: Deletions in the long arm of chromosome 11 are observed in a subgroup of advanced stage neuroblastomas with poor outcome. The deleted region harbours the tumour suppressor gene SDHD that is frequently mutated in paraganglioma and pheochromocytoma, which are, like neuroblastoma, tumours originating from the neural crest. In this study, we sought for evidence for involvement of SDHD in neuroblastoma....
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