Article
Loss of expression of SDHA predicts SDHA mutations in gastrointestinal stromal tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2013
Wagner Andrew J, Remillard Stephen P, Zhang Yi-Xiang, Doyle Leona A, George Suzanne, Hornick Jason L
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are usually driven by mutations in KIT or PDGFRA, although 15% of GISTs in adults and >90% in children lack such mutations. The majority of gastric KIT/PDGFRA wild-type GISTs show distinctive morphological and clinical features and loss of expression of succinate dehydrogenase (SDH) B. Only a small subset of SDHB-deficient GISTs carries loss-of-function mutations in SDHB,...
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