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The mitochondrial free radical theory of ageing--where do we stand?

Frontiers in bioscience : a journal and virtual library - 1 May 2008

Gruber Jan, Schaffer Sebastian, Halliwell Barry

Abstract excerpt

Understanding the molecular mechanisms underlying the ageing process may provide the best strategy for addressing the challenges posed by ageing populations worldwide. One theory proposing such molecular mechanisms was formulated 50 years ago. Harman et al. suggested that ageing might be mediated by macromolecular damage through reactions involving reactive oxygen species (ROS). Today, a version of the free...

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PMID: 18508680
DOI: 10.2741/3174

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