Article
Dissecting p53-dependent apoptosis.
Cell death and differentiation - 1 Jun 2006
Chipuk J E, Green D R
Abstract excerpt
The complexity of the p53 protein, coupled with the vast cellular responses to p53, is simply astonishing. As new isoforms, functional domains and protein-protein interactions are described; each morsel of information forces us to think (and re-think) about how it 'fits' into the current p53 paradigm. One aspect of p53 signaling that is under refinement is the mechanism(s) leading to apoptosis. Here we discuss...
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