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Article

Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis.

The Journal of biological chemistry - 11 Feb 2000

Munsch D, Watanabe-Fukunaga R, Bourdon J C, Nagata S, May E, Yonish-Rouach E, Reisdorf P

Abstract excerpt

p53 is a tumor suppressor protein that induces apoptosis at least in part through its ability to act as a sequence-specific transactivator. This work reports that intron 1 of the mouse Fas death receptor gene contains a p53-responsive element (p53RE) that matches the p53 consensus sequence and that is located between nucleotides +1704 and +1723 from the transcription initiation site. This element is specifically...

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Source

Identifiers

PMID: 10660538
DOI: 10.1074/jbc.275.6.3867

Genes

FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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