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Article

The kringle stabilizes urokinase binding to the urokinase receptor.

Blood - 15 Nov 2003

Bdeir Khalil, Kuo Alice, Sachais Bruce S, Rux Ann H, Bdeir Yasmina, Mazar Andrew, Higazi Abd Al-Roof, Cines Douglas B

Abstract excerpt

The structural basis of the interaction between single-chain urokinase-type plasminogen activator (scuPA) and its receptor (uPAR) is incompletely defined. Several observations indicated the kringle facilitates the binding of uPA to uPAR. A scuPA variant lacking the kringle (Delta K-scuPA) bound to soluble uPAR (suPAR) with the similar "on-rate" but with a faster "off-rate" than wild-type (WT)-scuPA. Binding of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Cell Surface

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Source

Identifiers

PMID: 12881310
DOI: 10.1182/blood-2003-03-0949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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