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Article

The Chemotactic Action of Urokinase on Smooth Muscle Cells Is Dependent on Its Kringle Domain

1 Jun 2000

Abstract excerpt

Urokinase plasminogen activator (uPA) is thought to exert its effects on cell growth, adhesion, and migration by mechanisms involving proteolysis and interaction with its cell surface receptor (uPAR). The functional properties of uPA and the significance of its various domains for chemotactic activity were analyzed using human airway smooth muscle cells (hAWSMC). The wild-type uPA (r-uPAwt), inactive urokinase...

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Share to Blood Coagulation and Thrombosis Mechanisms
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Identifiers

PMID: 10749881
DOI: 10.1074/jbc.m909080199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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