Article
Role of GHF-1 in the regulation of the rat growth hormone gene promoter by thyroid hormone and retinoic acid receptors.
The Journal of biological chemistry - 16 Oct 1998
Palomino T, Barettino D, Aranda A
Abstract excerpt
In non-pituitary HeLa cells the unliganded thyroid hormone or retinoic acid receptors cause a strong activation of the rat growth hormone promoter that is repressed by their ligands. In contrast, after expression of the pituitary-specific transcription factor GHF-1, thyroid hormone and retinoic a...
Topics
- Animals
- DNA-Binding Proteins
- Gene Expression Regulation
- Growth Hormone
- HeLa Cells
- Humans
- Ligands
- Mutation
- Peptide Fragments
- Promoter Regions, Genetic
- Rats
- Receptors, Retinoic Acid
- Receptors, Thyroid Hormone
- Recombinant Proteins
- Retinoid X Receptors
- Transcription Factor Pit-1
- Transcription Factors
- Triiodothyronine