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Article

Pituitary NR4A1 is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptors on the gene.

Molecular and cellular endocrinology - 5 Feb 2018

Okamura Takashi, Nakajima Yasuyo, Shibusawa Nobuyuki, Horiguchi Kazuhiko, Matsumoto Shunichi, Yamada Eijiro, Tomaru Takuya, Ishii Sumiyasu, Ozawa Atsushi, Ishizuka Takahiro, Hashimoto Koshi, Okada Shuichi, Satoh Tetsurou, Yamada Masanobu

Abstract excerpt

We previously reported that TRH stimulated pituitary TSHβ gene expression via an immediate increase in NR4A1 in thyrotrophs. We demonstrated that NR4A1 mRNA levels are regulated by thyroid hormone. Pituitary NR4A1 mRNA levels were decreased in mice injected with L-T4. NR4A1 promoter activity was increased by the overexpression of TRβs, and these increases were decreased by T3, and the -27∼+152 bp region was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28823847
DOI: 10.1016/j.mce.2017.08.007

Genes

TRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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