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Article

MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.

Oncotarget - 27 Sept 2016

Frottin Frédéric, Bienvenut Willy V, Bignon Jérôme, Jacquet Eric, Vaca Jacome Alvaro Sebastian, Van Dorsselaer Alain, Cianferani Sarah, Carapito Christine, Meinnel Thierry, Giglione Carmela

Abstract excerpt

Fumagillin and its derivatives are therapeutically useful because they can decrease cancer progression. The specific molecular target of fumagillin is methionine aminopeptidase 2 (MetAP2), one of the two MetAPs present in the cytosol. MetAPs catalyze N-terminal methionine excision (NME), an essential pathway of cotranslational protein maturation. To date, it remains unclear the respective contribution of MetAP1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27542228
DOI: 10.18632/oncotarget.11216
PMCID: PMC5325365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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