[Association between interleukin-1 composite genotype and severe periodontitis: case-control study].

Abstract excerpt

AIM: Interleukin-1 (IL-1) is a bone resorption stimulating cytokine that is implicated in the development of periodondal lesions. Recent studies suggest that the production of this mediator depends for quantity on a specific allelic combination in its genetic cluster. Periodontitis severity was correlated with the extent of the form 2 allele at the position -889 in the gene IL-1A, together with the form 2 allele...

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