Article
Allele, genotype, and composite genotype effects of IL-1A +4845 and IL-1B +3954 polymorphisms for chronic periodontitis in an Indian population.
Indian journal of dental research : official publication of Indian Society for Dental Research - 1 Jan 2000
Gayathri R, Saadi Abdul Vahab, Bhat K Mahalinga, Bhat Subraya G, Satyamoorthy Kapaettu
Abstract excerpt
INTRODUCTION: The pro-inflammatory cytokine interleukin-1 (IL-1) is a key modulator of host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption, and polymorphisms in the IL-1 gene cluster have been associated with an increased risk of developing severe adult periodontitis. A case control study was performed to determine the role of IL-1A+4845 and...
Topics
- Adult
- Alveolar Bone Loss
- Case-Control Studies
- Chronic Periodontitis
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Homozygote