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Article

Interleukin-1 genetic association with periodontitis in clinical practice.

Journal of periodontology - 1 Feb 2000

McDevitt M J, Wang H Y, Knobelman C, Newman M G, di Giovine F S, Timms J, Duff G W, Kornman K S

Abstract excerpt

BACKGROUND: Periodontitis is a bacterial disease modified by multiple risk factors. The pro-inflammatory cytokine interleukin- (IL-1) is a key regulator of the host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption. It has been reported that variations in the IL-1 gene cluster on chromosome 2 are associated with increased susceptibility to severe adult...

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Identifiers

PMID: 10711605
DOI: 10.1902/jop.2000.71.2.156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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