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Article

Interplay between the tumor suppressor p53 and TGFβ signaling shapes embryonic body axes in<i>Xenopus</i>

21 Jul 2003

Abstract excerpt

The transcription factor p53 has been shown to mediate cellular responses to diverse stresses such as DNA damage. However, the function of p53 in cellular differentiation in response to growth factor stimulations has remained obscure. We present evidence that p53 regulates cellular differentiation by modulating signaling of the TGF beta family of growth factors during early Xenopus embryogenesis. We show that p53...

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PMID: 12874116
DOI: 10.1242/dev.00615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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