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Article

p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells.

DNA and cell biology - 1 Feb 1998

Zhang L, Zhan Q, Zhan S, Kashanchi F, Fornace A J, Seth P, Helman L J

Abstract excerpt

The developmentally regulated human insulin-like growth factor II (IGFII) gene is expressed at high levels in many types of tumors and promotes the proliferation of tumor cells with a high incidence of p53 gene defects. We have previously shown that p53 inhibits IGFII P3 promoter activity and decreases endogenous IGFII gene expression derived from the P3 promoter in rhabdomyosarcomas by interfering with TBP...

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Share to DNA, Neoplasm
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Promoter Regions, Genetic

Share to Protein Binding

Share to RNA, Messenger

Share to Transcription, Genetic

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9502429
DOI: 10.1089/dna.1998.17.125

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells.PMID 9502429Read ↗

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