Control of Hepatic Differentiation by Activin/TGFβ Signaling

Abstract excerpt

During liver development, liver progenitors called hepatoblasts differentiate into hepatocytes or biliary cells. Recently, we showed that the segregation between hepatocytes and biliary cells is dependent on a gradient of Activin/TGFbeta signaling, and that Activin/TGFbeta signaling is controlled in fetal liver by transcription factors of the Onecut family. Here, we discuss candidate factors possibly involved in...

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