Article
p53 Suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2014
Caprio Cinzia, Baldini Antonio
Abstract excerpt
T-box 1 (Tbx1), a gene encoding a T-box transcription factor, is required for embryonic development in humans and mice. Half dosage of this gene in humans causes most of the features of the DiGeorge or Velocardiofacial syndrome phenotypes, including aortic arch and cardiac outflow tract abnormalities. Here we found a strong genetic interaction between Tbx1 and transformation related protein 53 (Trp53). Indeed,...
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