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Article

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2006

Jiang Zhengfan, Georgel Philippe, Li Chenglong, Choe Jungwoo, Crozat Karine, Rutschmann Sophie, Du Xin, Bigby Tim, Mudd Suzanne, Sovath Sosathya, Wilson Ian A, Olson Arthur, Beutler Bruce

Abstract excerpt

The immunovariant N-ethyl-N-nitrosourea-induced mutations Pococurante (Poc) and Lackadaisical were found to alter MyD88, creating striking receptor-selective effects. Poc, in particular, prevented sensing of all MyD88-dependent Toll-like receptor (TLR) ligands except diacyl lipopeptides. Furthermore, Poc-site and classical BB loop mutations caused equivalent phenotypes when engrafted into any TLR/IL-1...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Quaternary

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Source

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Identifiers

PMID: 16832055
DOI: 10.1073/pnas.0603804103
PMCID: PMC1544157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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