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Article

Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros.

Stem cells (Dayton, Ohio) - 1 Dec 2009

Papathanasiou Peter, Attema Joanne L, Karsunky Holger, Hosen Naoki, Sontani Yovina, Hoyne Gerard F, Tunningley Robert, Smale Stephen T, Weissman Irving L

Abstract excerpt

Hematopoietic stem cells (HSCs) are rare, ancestral cells that underlie the development, homeostasis, aging, and regeneration of the blood. Here we show that the chromatin-associated protein Ikaros is a crucial self-renewal regulator of the long-term (LT) reconstituting subset of HSCs. Ikaros, and associated family member proteins, are highly expressed in self-renewing populations of stem cells. Ikaros point...

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Source

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Identifiers

PMID: 19816952
DOI: 10.1002/stem.232
PMCID: PMC3401049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros.PMID 19816952Read ↗

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A Dominant-Negative Isoform of IKAROS Expands Primitive Normal Human Hematopoietic CellsSemantic proximity Read ↗

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