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Article

Defects in hemopoietic stem cell activity in Ikaros mutant mice.

The Journal of experimental medicine - 1 Nov 1999

Nichogiannopoulou A, Trevisan M, Neben S, Friedrich C, Georgopoulos K

Abstract excerpt

Here we provide evidence that the Ikaros family of DNA binding factors is critical for the activity of hemopoietic stem cells (HSCs) in the mouse. Mice homozygous for an Ikaros null mutation display a >30-fold reduction in long-term repopulation units, whereas mice homozygous for an Ikaros dominant negative mutation have no measurable activity. The defect in HSC activity is also illustrated by the ability of...

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Identifiers

PMID: 10544193
DOI: 10.1084/jem.190.9.1201
PMCID: PMC2195677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defects in hemopoietic stem cell activity in Ikaros mutant mice.PMID 10544193Read ↗

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