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Article

Role of Baseline pol Genotype in HIV-1 Fitness Evolution.

Journal of acquired immune deficiency syndromes (1999) - 1 Aug 2003

Weber Jan, Rangel Hector R, Chakraborty Bikram, Marotta Michael L, Valdez Hernan, Fransen Katrien, Florence Eric, Connick Elizabeth, Smith Kimberly Y, Colebunders Robert L, Landay Alan, Kuritzkes Daniel R, Lederman Michael M, Vanham Guido, Quiñones-Mateu Miguel E

Abstract excerpt

Viral fitness can be modified upon development of antiretroviral drug resistance, usually by selection of compensatory mutations. In this study, we have used HIV-1 isolates from individuals receiving a protease inhibitor (PI)-based regimen to analyze the impact of basal genetic background on viral fitness evolution. Paired plasma samples and HIV-1 isolates were obtained from 10 PI-naive HIV-infected individuals...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12869833
DOI: 10.1097/00126334-200308010-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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