Article
Role of Baseline pol Genotype in HIV-1 Fitness Evolution.
Journal of acquired immune deficiency syndromes (1999) - 1 Aug 2003
Weber Jan, Rangel Hector R, Chakraborty Bikram, Marotta Michael L, Valdez Hernan, Fransen Katrien, Florence Eric, Connick Elizabeth, Smith Kimberly Y, Colebunders Robert L, Landay Alan, Kuritzkes Daniel R, Lederman Michael M, Vanham Guido, Quiñones-Mateu Miguel E
Abstract excerpt
Viral fitness can be modified upon development of antiretroviral drug resistance, usually by selection of compensatory mutations. In this study, we have used HIV-1 isolates from individuals receiving a protease inhibitor (PI)-based regimen to analyze the impact of basal genetic background on vira...
Topics
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Base Sequence
- CD4 Lymphocyte Count
- Genes, env
- Genes, pol
- Genetic Variation
- Genotype
- HIV Protease Inhibitors
- HIV-1
- Humans
- Molecular Sequence Data
- RNA, Viral