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Article

Fitness of human immunodeficiency virus type 1 protease inhibitor-selected single mutants.

Virology - 30 Sept 2000

Martinez-Picado J, Savara A V, Shi L, Sutton L, D'Aquila R T

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) evolution under chemotherapeutic selection pressure in vivo involves a complex interplay between an increasing magnitude of drug resistance and changes in viral replicative capacity. To examine the replicative fitness of HIV-1 mutants with single, drug-selected substitutions in protease (PR), we constructed virus that contained the most common mutations in...

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Identifiers

PMID: 10998332
DOI: 10.1006/viro.2000.0527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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