Article
HLA class II molecules and autoimmune hepatitis susceptibility in Japanese patients.
Gastroenterology - 1 Sept 1992
Seki T, Ota M, Furuta S, Fukushima H, Kondo T, Hino K, Mizuki N, Ando A, Tsuji K, Inoko H
Abstract excerpt
To investigate the association between autoimmune hepatitis and HLA alleles in Japanese patients, serological typing and class II genotyping were performed using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method. Serological typing showed that HLA-B54, -DR4, -DR53, and -DQ4 were significantly more frequent in patients with autoimmune hepatitis than in controls. HLA-DR4 was...
Topics
- Adult
- Aged
- Alleles
- Autoimmune Diseases
- Biomarkers
- Disease Susceptibility
- Female
- Gene Frequency
- Genotype
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR4 Antigen