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Article

Nitric oxide suppresses apoptosis in human colon cancer cells by scavenging mitochondrial superoxide anions.

International journal of cancer - 20 Sept 2003

Wenzel Uwe, Kuntz Sabine, De Sousa Ulrike Jambor, Daniel Hannelore

Abstract excerpt

In cells lacking a functional p53 tumor suppressor protein, the endogenous free radical nitric oxide (NO) appears to inhibit apoptosis, and thereby promotes growth of cancer cells. In order to elucidate the underlying mechanisms on a molecular basis, we used HT-29 human colon carcinoma cells, carrying a p53 loss-of-function mutation, and examined the effects of NO on apoptosis when induced either by the flavonoid...

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PMID: 12866025
DOI: 10.1002/ijc.11294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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