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Nitric oxide induces cyclooxygenase expression and inhibits cell growth in colon cancer cell lines

1 Apr 2003

Abstract excerpt

The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relationship with NO has never been studied in colon cancer. Three colon cancer cell lines (HCA7, HT29 and...

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PMID: 12727790
DOI: 10.1093/carcin/bgg014

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