Article
Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species-independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells.
Nutrition research (New York, N.Y.) - 1 Mar 2018
Agarwal Ayushi, Kasinathan Akiladdevi, Ganesan Ramamoorthi, Balasubramanian Akhila, Bhaskaran Jahnavi, Suresh Samyuktha, Srinivasan Revanth, Aravind K B, Sivalingam Nageswaran
Abstract excerpt
Curcumin is a natural dietary polyphenol compound that has various pharmacological activities such as antiproliferative and cancer-preventive activities on tumor cells. Indeed, the role reactive oxygen species (ROS) generated by curcumin on cell death and cell proliferation inhibition in colon cancer is poorly understood. In the present study, we hypothesized that curcumin-induced ROS may promote apoptosis and...
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