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2′‐Hydroxyflavanone induces apoptosis through <scp>E</scp>gr‐1 involving expression of <scp>B</scp>ax, p21, and <scp>NAG</scp>‐1 in colon cancer cells

1 May 2012

Abstract excerpt

SCOPE: Natural flavanones exhibit cancer preventive and/or therapeutic effects. The objective of this study was to investigate the molecular mechanism underlying the action of the antitumor activity of hydroxyflavanone using the HCT116 colon cancer cell line. METHODS AND RESULTS: We investigated the effect of hydroxyflavanones on antitumor activity. We found that 2'-hydroxyflavanone (2'-HF) potently inhibited the...

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PMID: 22648623
DOI: 10.1002/mnfr.201100651

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