Article
A novel variable number of tandem repeat polymorphism of the renin gene and essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jun 2003
Hasimu Buaijiaer, Nakayama Tomohiro, Mizutani Yoshihiro, Izumi Yoichi, Asai Satoshi, Soma Masayoshi, Kokubun Shinichiro, Ozawa Yukio
Abstract excerpt
The aims of the present study were to find new genetic markers of essential hypertension (EH) and to investigate relationships between EH and polymorphisms of the renin gene. Using single strand conformation polymorphism, we discovered a new variable number of tandem repeat (VNTR) polymorphism in intron 7 that is 18 bp upstream from the boundary with exon 8. Nucleotide sequencing revealed that this VNTR...
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