Article

Persistent virus-specific and clonally expanded antibody secreting cells respond to induced self antigen in the CNS

2022-08-29

Abstract excerpt

B cells contribute to the pathogenesis of both cellular- and humoral-mediated central nervous system (CNS) inflammatory diseases through a variety of mechanisms. In such conditions, B cells may enter the CNS parenchyma and contribute to local tissue destruction. It remains unexplored, however, how infection and autoimmunity drive transcriptional phenotypes, repertoire features, and antibody functionality. Here, we...

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Literature Corpus work: 685cb9df-ca37-5473-bfd0-6cdc64f85c04
DOI: 10.1101/2022.08.29.505678

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