Article
Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression.
Molecular and cellular biology - 1 Dec 1997
Riley D J, Liu C Y, Lee W H
Abstract excerpt
To assess biological roles of the retinoblastoma protein (RB), four independent transgenic mouse lines expressing human RB with different deletions in the N-terminal region (RBdeltaN) were generated and compared with mice expressing identically regulated, full-length RB. Expression of both RB and RBdeltaN caused developmental growth retardation, but the wild-type protein was more potent. In contrast to wild-type...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Differentiation
- DNA Primers
- Disease Models, Animal
- Female
- Gene Expression
- Genes, Lethal
- Genotype
- Growth
- Humans
- Mice
- Mice, Transgenic