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Article

Rhodopsin mutants that bind but fail to activate transducin.

Science (New York, N.Y.) - 5 Oct 1990

Franke R R, König B, Sakmar T P, Khorana H G, Hofmann K P

Abstract excerpt

Rhodopsin is a member of a family of receptors that contain seven transmembrane helices and are coupled to G proteins. The nature of the interactions between rhodopsin mutants and the G protein, transduction (Gt), was investigated by flash photolysis in order to monitor directly Gt binding and dissociation. Three mutant opsins with alterations in their cytoplasmic loops bound 11-cis-retinal to yield pigments with...

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Identifiers

PMID: 2218504
DOI: 10.1126/science.2218504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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