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Article

Transcriptional upregulation of interferon-induced protein kinase, PKR, in breast cancer.

Cancer letters - 10 Jul 2003

Nussbaum Jean M, Major Marian, Gunnery Shobha

Abstract excerpt

PKR (double-stranded RNA activated protein kinase) is overexpressed and overactive in human breast carcinoma (BC) cells. Here, we report that BC cells also have higher PKR mRNA levels and exhibit increased transcription from the PKR promoter. Mutational analysis of the PKR promoter indicated that the interferon stimulation response element (ISRE) is responsible for the increased transcription in BC cells. By gel...

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Source

Identifiers

PMID: 12860279
DOI: 10.1016/s0304-3835(03)00276-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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