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Article

<i>PKR</i> , a <i>p53</i> target gene, plays a crucial role in the tumor-suppressor function of <i>p53</i>

24 Apr 2009

Abstract excerpt

Type I IFN-induced expression of dsRNA-activated protein kinase (PKR) during viral infection is a well-established antiviral mechanism. However, little is known about the expression of PKR in the context of p53 and about PKR involvement in p53-mediated tumor suppression. Here, we report that PKR is a p53 target gene and plays an important role in the tumor-suppressor function of p53. Activation of p53 by...

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Identifiers

PMID: 19416861
DOI: 10.1073/pnas.0812148106

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<i>PKR</i> , a <i>p53</i> target gene, plays a crucial role in the tumor-suppressor function of <i>p53</i>PMID 19416861Read ↗

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