Article
Single-cell mRNA cytometry via sequence-specific nanoparticle clustering and trapping.
Nature chemistry - 1 May 2018
Labib Mahmoud, Mohamadi Reza M, Poudineh Mahla, Ahmed Sharif U, Ivanov Ivaylo, Huang Ching-Lung, Moosavi Maral, Sargent Edward H, Kelley Shana O
Abstract excerpt
Cell-to-cell variation in gene expression creates a need for techniques that can characterize expression at the level of individual cells. This is particularly true for rare circulating tumour cells, in which subtyping and drug resistance are of intense interest. Here we describe a method for cell analysis-single-cell mRNA cytometry-that enables the isolation of rare cells from whole blood as a function of target...
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