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Article

Effect of a cleavage-resistant collagen mutation on left ventricular remodeling.

Circulation research - 8 Aug 2003

Lindsey Merry L, Yoshioka Jun, MacGillivray Catherine, Muangman Suphichaya, Gannon Joseph, Verghese Anjali, Aikawa Masanori, Libby Peter, Krane Stephen M, Lee Richard T

Abstract excerpt

Matrix metalloproteinase-mediated degradation of type I collagen may play a role in cardiac remodeling after strain or injury. To explore this hypothesis, we used mice homozygous (r/r) for a targeted mutation in Col1a1; these mice synthesize collagen I that resists collagenase cleavage at Gly975-...

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Source

Identifiers

PMID: 12855673
DOI: 10.1161/01.RES.0000085580.45279.60

Genes

ESD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12855673-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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