Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prognostic significance of the F‐box protein Skp2 expression in diffuse large B‐cell lymphoma

18 Jul 2003

Abstract excerpt

The F-box protein Skp2 positively regulates the G1-S transition by promoting degradation of the cyclin-dependent kinase inhibitor p27(kip1) (p27). Recent evidence has suggested an oncogenic role of Skp2 in not only carcinogenesis but also lymphomagenesis. In this study, we performed immunohistochemical analysis on the cell-cycle-associated proteins, Skp2, p27, and Ki-67, in 27 patients with de novo diffuse large...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways
Share to Lymphoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12879424
DOI: 10.1002/ajh.10379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic significance of the F‐box protein Skp2 expression in diffuse large B‐cell lymphomaPMID 12879424Read ↗

Role of the F-box protein Skp2 in lymphomagenesisSemantic proximity Read ↗

Regulation of Skp2 Expression and Activity and Its Role in Cancer ProgressionSemantic proximity Read ↗

Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasisSemantic proximity Read ↗

SKping cell cycle regulation: role of ubiquitin ligase SKP2 in hematological malignanciesSemantic proximity Read ↗

Skp2 is oncogenic and overexpressed in human cancersSemantic proximity Read ↗

Skp2/p27 expression profile is correlated with Epstein-Barr virus status in extranodal nasal-type natural killer cell lymphoma.Semantic proximity Read ↗

Skp2 regulates G2/M progression in a p53-dependent manner.Semantic proximity Read ↗

High S phase kinase‑associated protein 2 expression is a potential prognostic biomarker for gliomaSemantic proximity Read ↗

SKP2 Oncogene Is a Direct MYC Target Gene and MYC Down-regulates p27KIP1 through SKP2 in Human Leukemia CellsSemantic proximity Read ↗

Skp2 overexpression is a p27<sup>Kip1</sup>‐independent predictor of poor prognosis in patients with biliary tract cancersSemantic proximity Read ↗

The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclin E and regulates ubiquitin-dependent degradation of cyclin E.Semantic proximity Read ↗

Skp2 Inhibitors: Novel Anticancer StrategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.