Article
Simultaneous on/off regulation of transgenes located on a mammalian chromosome with Cre-expressing adenovirus and a mutant loxP.
Nucleic acids research - 15 Jul 2003
Kondo Saki, Okuda Aya, Sato Hiromi, Tachikawa Naoto, Terashima Miho, Kanegae Yumi, Saito Izumu
Abstract excerpt
The site-specific recombinase Cre has often been used for on/off regulation of expression of transgenes introduced into the mammalian chromosome. However, this method is only applicable to the regulation of a single gene and cannot be used to simultaneously regulate two genes, because site-specific recombination occurs from the target loxP sequence of one regulating unit to the loxP sequence of any other unit and...
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