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Article

Separate control of Rep and Cap expression using mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.

Molecular biotechnology - 1 May 2004

Mizukami Hiroaki, Okada Takashi, Ogasawara Yoji, Matsushita Takashi, Urabe Masashi, Kume Akihiro, Ozawa Keiya

Abstract excerpt

Adeno-associated virus (AAV) vectors are a practical choice for gene transfer, and demand for them is increasing. To cope with the necessity in the near future, we have developed a number of approaches to establish packaging cell lines for the production of AAV vectors. In our previous study, a highly regulated expression of large Rep proteins was obtained by using the Cre-loxP switching system. Therefore, in the...

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PMID: 15122043
DOI: 10.1385/MB:27:1:07

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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