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Article

Replication of damaged DNA in vitro is blocked by p53.

Nucleic acids research - 15 Jul 2003

Zhou Jianmin, Prives Carol

Abstract excerpt

The tumor suppressor protein p53 may have other roles and functions in addition to its well-documented ability to serve as a sequence-specific transcriptional activator in response to DNA damage. We showed previously that p53 can block the replication of polyomavirus origin-containing DNA (Py ori-DNA) in vitro when p53 binding sites are present on the late side of the Py ori. Here we have both further extended...

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Identifiers

PMID: 12853603
DOI: 10.1093/nar/gkg468
PMCID: PMC165982

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Source receipt: pubmed, retrieved 7 Sept 2026.

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