Article
Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression.
The EMBO journal - 15 Jul 2003
Gabellini Davide, Colaluca Ivan N, Vodermaier Hartmut C, Biamonti Giuseppe, Giacca Mauro, Falaschi Arturo, Riva Silvano, Peverali Fiorenzo A
Abstract excerpt
Hox proteins are transcription factors involved in controlling axial patterning, leukaemias and hereditary malformations. Here, we show that HOXC10 oscillates in abundance during the cell cycle, being targeted for degradation early in mitosis by the ubiquitin-dependent proteasome pathway. Among abdominal-B subfamily members, the mitotic proteolysis of HOXC10 appears unique, since the levels of the paralogous...
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