Article
Identification of polymorphisms on the MDR1 gene among Turkish population and their effects on multidrug resistance in acute leukemia patients.
American journal of hematology - 1 Sept 2005
Kaya Pelin, Gündüz Ufuk, Arpaci Fikret, Ural Ali Uĝur, Guran Sefik
Abstract excerpt
Multidrug-resistance (MDR) phenotype is a serious limitation to the effective chemotherapeutic treatment of many cancer types, including leukemia. One of the most important proteins, the over-expression of which is responsible for the multidrug-resistance phenotype in many cancer types, is P-glyc...
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