Article
MDR1 C3435T polymorphism in Mexican children with acute lymphoblastic leukemia and in healthy individuals.
Human biology - 1 Aug 2008
Leal-Ugarte Evelia, Gutiérrez-Angulo Melva, Macías-Gómez Nelly M, Peralta-Leal Valeria, Durán-González Jorge, De La Luz Ayala-Madrigal María, Partida-Pérez Miriam, Barros-Núñez Patricio, Ruiz-Díaz Dinorah, Moreno-Ortiz José M, Peregrina-Sandoval Jorge, Meza-Espinoza Juan Pablo
Abstract excerpt
To determine the influence of the MDR1 C3435T polymorphism on the development of childhood acute lymphoblastic leukemia (ALL), we studied 107 children with ALL and 111 healthy subjects. All subjects were genotyped for the C3435T polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method. The genotype frequencies in the patients were 17% homozygous CC, 61% heterozygous CT, and...
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