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Article

Multi-drug transporter MDR1 gene polymorphism and prognosis in adult acute lymphoblastic leukemia.

Pharmacological reports : PR - 1 Jan 2000

Jamroziak Krzysztof, Balcerczak Ewa, Cebula Barbara, Kowalczyk Monika, Panczyk Mariusz, Janus Agnieszka, Smolewski Piotr, Mirowski Marek, Robak Tadeusz

Abstract excerpt

P-glycoprotein (P-gp), a membrane transporter encoded by MDR1 gene, influences pharmacokinetics of anti-cancer drugs and contributes to multi-drug resistance phenotype in adult acute lymphoblastic leukemia (ALL). In this study, we explored prognostic and functional role of single nucleotide polymorphism C3435T in MDR1 gene in 44 adult Caucasian patients with ALL. We found that the outcome of chemotherapy as well...

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PMID: 16382213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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