Article
Phenotypic mismatch repair hMSH2 and hMLH1 gene expression profiles in primary non-small cell lung carcinomas.
Lung cancer (Amsterdam, Netherlands) - 1 Jun 2009
Vageli Dimitra, Daniil Zoe, Dahabreh Jubrail, Karagianni Eleni, Vamvakopoulou Dimitra N, Ioannou Maria G, Scarpinato Karin, Vamvakopoulos Nikos C, Gourgoulianis Konstantinos I, Koukoulis George K
Abstract excerpt
BACKGROUND: Defects in the human DNA mismatch repair genes (MMR) hMSH2 and hMLH1 are responsible for the development of sporadic and hereditary colorectal cancers. The role of MMR genes in the pathogenesis of lung cancer has not been elucidated. The aim of this study was to address the phenotypic mRNA expression profiles of mismatch DNA repair system in lung cancer. MATERIALS AND METHODS: We evaluated the mRNA...
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