Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Steady-state Regulation of the Human DNA Mismatch Repair System

1 Jun 2000

Abstract excerpt

Steady-state levels of human DNA mismatch repair (MMR) transcripts and proteins were measured in MMR-proficient and -deficient cell lines by the newly developed competitive quantitative reverse transcription- polymerase chain reaction and Western analysis normalized with purified proteins. In MMR-proficient cells, hMSH2 is the most abundant MMR protein and is expressed 3 to 5 times more than hMLH1. The hMLH1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10747992
DOI: 10.1074/jbc.m001140200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Steady-state Regulation of the Human DNA Mismatch Repair SystemPMID 10747992Read ↗

The Human Mismatch Recognition Complex hMSH2-hMSH6 Functions as a Novel Molecular SwitchSemantic proximity Read ↗

The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancerSemantic proximity Read ↗

MutS homologues hMSH4 and hMSH5: diverse functional implications in humans.Semantic proximity Read ↗

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6Semantic proximity Read ↗

The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicaseSemantic proximity Read ↗

Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction.Semantic proximity Read ↗

ATM-Mediated Stabilization of hMutL DNA Mismatch Repair Proteins Augments p53 Activation during DNA DamageSemantic proximity Read ↗

Oxidative stress inactivates the human DNA mismatch repair systemSemantic proximity Read ↗

Mismatch repair protein hMSH2–hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediateSemantic proximity Read ↗

Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.Semantic proximity Read ↗

Mutations in mismatch repair genes are involved in the neoplastic transformation of human breast epithelial cells.Semantic proximity Read ↗

The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.