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Article

Akt signaling regulates side population cell phenotype via Bcrp1 translocation.

The Journal of biological chemistry - 3 Oct 2003

Mogi Masaki, Yang Jiang, Lambert Jean-Francois, Colvin Gerald A, Shiojima Ichiro, Skurk Carsten, Summer Ross, Fine Alan, Quesenberry Peter J, Walsh Kenneth

Abstract excerpt

Akt is an important regulator of cell survival, growth, and glucose metabolism in many cell types, but the role of this signaling molecule in hematopoietic stem cells is poorly defined. Side population (SP) cells are enriched for hematopoietic stem cell activity and are defined by their ability to efficiently efflux Hoechst 33342. Bone marrow from Akt1-null mice exhibited a reduced SP fraction. However, bone...

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PMID: 12851395
DOI: 10.1074/jbc.M306362200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Akt signaling regulates side population cell phenotype via Bcrp1 translocation.PMID 12851395Read ↗

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