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Article

Age-Dependent Increase in Side Population Distribution Within Hematopoiesis: Implications for Our Understanding of the Mechanism of Aging

7 Dec 2006

Abstract excerpt

It is thought that, as we age, damage to our stem cells may lead to diminished stem cell pool function and, consequently, a reduced organ regeneration potential that contributes to somatic senescence. Stem cells have evolved many antitoxicity mechanisms, and certain mechanisms may be utilized to isolate hematopoietic stem cells. One method exploits the activity of the ATP-binding cassette/G2 transporter to efflux...

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PMID: 17158238
DOI: 10.1634/stemcells.2006-0405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Age-Dependent Increase in Side Population Distribution Within Hematopoiesis: Implications for Our Understanding of the Mechanism of AgingPMID 17158238Read ↗

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Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell PopulationsSemantic proximity Read ↗

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Detection and enrichment of hematopoietic stem cells by side population phenotype.Semantic proximity Read ↗

A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemiaSemantic proximity Read ↗

Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo.Semantic proximity Read ↗

Side population in adult murine epidermis exhibits phenotypic and functional characteristics of keratinocyte stem cells.Semantic proximity Read ↗

Erythroblasts highly express the ABC transporter Bcrp1/ABCG2 but do not show the side population (SP) phenotype.Semantic proximity Read ↗

Identification and characterization of side population cells in embryonic stem cell cultures.Semantic proximity Read ↗

Side Population in Human Lung Cancer Cell Lines and Tumors Is Enriched with Stem-like Cancer CellsSemantic proximity Read ↗

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