Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia

15 Aug 2001

Abstract excerpt

The hematopoietic stem cell underlying acute myeloid leukemia (AML) is controversial. Flow cytometry and the DNA-binding dye Hoechst 33342 were previously used to identify a distinct subset of murine hematopoietic stem cells, termed the side population (SP), which rapidly expels Hoechst dye and can reconstitute the bone marrow of lethally irradiated mice. Here, the prevalence and pathogenic role of SP cells in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Cancer Cells and Metastasis
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11493466
DOI: 10.1182/blood.v98.4.1166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemiaPMID 11493466Read ↗

Harnessing the DNA Dye-triggered Side Population Phenotype to Detect and Purify Cancer Stem Cells from Biological Samples.Semantic proximity Read ↗

Side population/ABCG2-positive cells represent a heterogeneous group of haemopoietic cells: implications for the use of adult stem cells in transplantation and plasticity protocols.Semantic proximity Read ↗

A distinct “side population” of cells with high drug efflux capacity in human tumor cellsSemantic proximity Read ↗

Side Population Cells as Prototype of Chemoresistant, Tumor-Initiating CellsSemantic proximity Read ↗

Detection and enrichment of hematopoietic stem cells by side population phenotype.Semantic proximity Read ↗

Kinetic analyses as a critical parameter in defining the side population (SP) phenotype.Semantic proximity Read ↗

A side order of stem cells: the SP phenotype.Semantic proximity Read ↗

Targeting of Leukemia-Initiating Cells to Develop Curative Drug Therapies: Straightforward but Nontrivial ConceptSemantic proximity Read ↗

Side Population in Human Lung Cancer Cell Lines and Tumors Is Enriched with Stem-like Cancer CellsSemantic proximity Read ↗

SALL4, a Stem Cell Factor, Affects the Side Population by Regulation of the ATP-Binding Cassette Drug Transport GenesSemantic proximity Read ↗

Age-Dependent Increase in Side Population Distribution Within Hematopoiesis: Implications for Our Understanding of the Mechanism of AgingSemantic proximity Read ↗

Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell PopulationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.