Article
Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha.
The Biochemical journal - 1 May 2005
Cranmer Susan L, Pikovski Inna, Mangin Pierre, Thompson Philip E, Domagala Teresa, Frazzetto Mark, Salem Hatem H, Jackson Shaun P
Abstract excerpt
Binding of the platelet GPIb/V/IX (glycoprotein Ib/V/IX) receptor to von Willebrand factor is critical for platelet adhesion and aggregation under conditions of rapid blood flow. The adhesive function of GPIbalpha is regulated by its anchorage to the membrane skeleton through a specific interaction with filamin A. In the present study, we examined the amino acid residues within the cytoplasmic tail of GPIbalpha,...
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